Article
Tumour mutations in long noncoding RNAs enhance cell fitness.
Nature communications - 8 Jun 2023
Esposito Roberta, Lanzós Andrés, Uroda Tina, Ramnarayanan Sunandini, Büchi Isabel, Polidori Taisia, Guillen-Ramirez Hugo, Mihaljevic Ante, Merlin Bernard Mefi, Mela Lia, Zoni Eugenio, Hovhannisyan Lusine, McCluggage Finn, Medo Matúš, Basile Giulia, Meise Dominik F, Zwyssig Sandra, Wenger Corina, Schwarz Kyriakos, Vancura Adrienne, Bosch-Guiteras Núria, Andrades Álvaro, Tham Ai Ming, Roemmele Michaela, Medina Pedro P, Ochsenbein Adrian F, Riether Carsten, Kruithof-de Julio Marianna, Zimmer Yitzhak, Medová Michaela, Stroka Deborah, Fox Archa, Johnson Rory
Abstract excerpt
Long noncoding RNAs (lncRNAs) are linked to cancer via pathogenic changes in their expression levels. Yet, it remains unclear whether lncRNAs can also impact tumour cell fitness via function-altering somatic "driver" mutations. To search for such driver-lncRNAs, we here perform a genome-wide analysis of fitness-altering single nucleotide variants (SNVs) across a cohort of 2583 primary and 3527 metastatic tumours....
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