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Analysis of 7,815 cancer exomes reveals associations between mutational processes and somatic driver mutations

9 Nov 2018

Abstract excerpt

Driver mutations are the genetic variants responsible for oncogenesis, but how specific somatic mutational events arise in cells remains poorly understood. Mutational signatures derive from the frequency of mutated trinucleotides in a given cancer sample, and they provide an avenue for investigating the underlying mutational processes that operate in cancer. Here we analyse somatic mutations from 7,815 cancer...

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PMID: 30412573
DOI: 10.1371/journal.pgen.1007779

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