Article
Single-cell transcriptome profiling reveals vascular endothelial cell heterogeneity in human skin.
Theranostics - 1 Jan 2021
Li Qingyang, Zhu Zhenlai, Wang Lei, Lin Yiting, Fang Hui, Lei Jie, Cao Tianyu, Wang Gang, Dang Erle
Abstract excerpt
Vascular endothelial cells (ECs) are increasingly recognized as active players in intercellular crosstalk more than passive linings of a conduit for nutrition delivery. Yet, their functional roles and heterogeneity in skin remain uncharacterized. We have used single-cell RNA sequencing (scRNA-seq) as a profiling strategy to investigate the tissue-specific features and intra-tissue heterogeneity in dermal ECs at...
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