Gene Expression Signature in Patients With Symptomatic Peripheral Artery Disease

Abstract excerpt

Objective: Peripheral artery disease (PAD) is an atherothrombotic disease of the lower limbs with substantial morbidity and mortality. We used next-generation sequencing to identify genome-wide expression signatures associated with prevalent PAD and its outcomes. Approach and Results: We performed whole blood RNA sequencing among patients with severe symptomatic PAD undergoing lower extremity revascularization...

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