Article

Efficient genome editing of human natural killer cells by CRISPR RNP

2018-09-06

Abstract excerpt

The ability to genetically modify CD8 T cells using viral gene delivery has facilitated the development of next generation of cancer immunotherapies such as chimeric antigen receptor (CAR) T cells engineered to specifically kill tumor cells. Development of immunotherapies targeting natural killer (NK) cells have stalled in part by their resistance to viral gene delivery. Here, we describe an efficient approach to...

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Literature Corpus work: 16e99b97-a7a2-5a1d-86f2-0e2ad50a7d12
DOI: 10.1101/406934

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