Article

Rotational 3D mechanogenomic Turing patterns of human colon Caco-2 cells during differentiation

2018-02-26

Abstract excerpt

Recent reports suggest that actomyosin meshwork act in a mechanobiological manner alter cell/nucleus/tissue morphology, including human colon epithelial Caco-2 cancer cells that form polarized 2D epithelium or 3D sphere/tube when placed in different culture conditions. We observed the rotational motion of the nucleus in Caco-2 cells in vitro that appears to be driven by actomyosin network prior to the formation of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16e657bd-02ec-54fd-99e2-5661632fa04d
DOI: 10.1101/272096

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rotational 3D mechanogenomic Turing patterns of human colon Caco-2 cells during differentiationDOI 10.1101/272096Read

Single-cell transcriptomic mapping of intestinal epithelium that undergoes 3D morphogenesis and mechanodynamic stimulation in a gut-on-a-chipSemantic proximity Read

Single-cell transcriptomics elucidates <i>in vitro</i> reprogramming of human intestinal epithelium cultured in a physiodynamic gut-on-a-chipSemantic proximity Read

3D in vitro morphogenesis of human intestinal epithelium in a gut-on-a-chip or a hybrid chip with a cell culture insertSemantic proximity Read

Changes in cellular mechanical properties during onset or progression of colorectal cancer.Semantic proximity Read

Steps in Mechanotransduction Pathways that Control Cell MorphologySemantic proximity Read

Contractile forces at tricellular contacts modulate epithelial organization and monolayer integritySemantic proximity Read

Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures.Semantic proximity Read

Mechanostimulatory cues determine intestinal fibroblast fate and profibrotic remodeling in a physiodynamic human gut-on-a-chipSemantic proximity Read

Coherent angular motion in the establishment of multicellular architecture of glandular tissuesSemantic proximity Read

Deciphering interplay between biology and physics: finite element method-implemented vertex organoid model raises the challengeSemantic proximity Read

Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAPSemantic proximity Read

Extracellular matrix flow guides emergent in-vitro morphogenesisSemantic proximity Read