Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Origins, genetic landscape, and emerging therapies of small cell lung cancer.

Genes & development - 15 Jul 2015

Semenova Ekaterina A, Nagel Remco, Berns Anton

Abstract excerpt

Lung cancer is the leading cause of cancer deaths, with small cell lung cancer (SCLC) representing the most aggressive subtype. Standard treatments have not changed in decades, and the 5-year survival rate has remained <7%. Genomic analyses have identified key driver mutations of SCLC that were subsequently validated in animal models of SCLC. To provide better treatment options, a deeper understanding of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Disease Models, Animal
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Neoplasms

Share to Mutation

Share to Small Cell Lung Carcinoma

Source

Open in PubMed Open full text

Identifiers

PMID: 26220992
DOI: 10.1101/gad.263145.115
PMCID: PMC4526731

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Origins, genetic landscape, and emerging therapies of small cell lung cancer.PMID 26220992Read ↗

The molecular pathogenesis of small cell lung cancerSemantic proximity Read ↗

Small cell lung cancer: emerging subtypes, signaling pathways, and therapeutic vulnerabilitiesSemantic proximity Read ↗

Advances in Small-Cell Lung Cancer (SCLC) Translational Research.Semantic proximity Read ↗

Small Cell Lung Cancer: State of the Art of the Molecular and Genetic Landscape and Novel PerspectiveSemantic proximity Read ↗

Molecular subtyping of small cell lung cancer.Semantic proximity Read ↗

Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin.Semantic proximity Read ↗

Molecular and Genetic Advances in Small Cell Lung Cancer Landscape: From Homogeneity to Diversity.Semantic proximity Read ↗

Current knowledge of small cell lung cancer transformation from non-small cell lung cancer.Semantic proximity Read ↗

Molecular classification of small cell lung cancer subtypes: Characteristics, prognostic factors, and clinical translation.Semantic proximity Read ↗

Molecular profiles of small cell lung cancer subtypes: Therapeutic implicationsSemantic proximity Read ↗

Targeted therapies for small cell lung cancer: Where do we stand?Semantic proximity Read ↗

Cellular and molecular biology of small cell lung cancer: an overview.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.