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Article

An update on the pathomechanisms and future therapies of Alport syndrome.

Pediatric nephrology (Berlin, Germany) - 1 Jul 2013

Noone Damien, Licht Christoph

Abstract excerpt

Alport Syndrome (AS) is an inherited progressive disease that is caused by mutations of the genes encoding the key collagen chains, α3, α4, and α5, which are necessary for the composition of collagen type IV to form a robust glomerular basement membrane (GBM), capable of withstanding the significant biomechanical strain to which the glomerulus is subjected. Progressive loss of the filtration barrier allows...

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Share to Angiotensin-Converting Enzyme Inhibitors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22903660
DOI: 10.1007/s00467-012-2272-z

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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