Article

Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis

2010-06-01

Abstract excerpt

Phthiocerol and phthiodiolone dimycocerosates (DIMs) and phenolic glycolipids (PGLs) are complex lipids located at the cell surface of Mycobacterium tuberculosis that play a key role in the pathogenicity of tuberculosis. Most of the genes involved in the biosynthesis of these compounds are clustered on a region of the M. tuberculosis chromosome, the so-called DIM + PGL locus. Among these genes, four ORFs encode Fa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16a56c7b-a366-5126-8af0-ca3b4a2776aa
DOI: 10.1111/j.1742-464x.2010.07688.x

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosisDOI 10.1111/j.1742-464x.2010.07688.xRead

Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosisSemantic proximity Read

Identification of the missing trans-acting enoyl reductase required for phthiocerol dimycocerosate and phenolglycolipid biosynthesis in Mycobacterium tuberculosis.Semantic proximity Read

Analysis of the Phthiocerol Dimycocerosate Locus ofMycobacterium tuberculosisSemantic proximity Read

Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complex.Semantic proximity Read

Biosynthesis of cell envelope-associated phenolic glycolipids in Mycobacterium marinum.Semantic proximity Read

Characterization of three glycosyltransferases involved in the biosynthesis of the phenolic glycolipid antigens from the Mycobacterium tuberculosis complex.Semantic proximity Read

Multiple deletions in the polyketide synthase gene repertoire of<i>Mycobacterium tuberculosis</i>reveal functional overlap of cell envelope lipids in host-pathogen interactionsSemantic proximity Read

Both phthiocerol dimycocerosates and phenolic glycolipids are required for virulence of Mycobacterium marinum.Semantic proximity Read

Biosynthesis of mycobacterial lipids by polyketide synthases and beyondSemantic proximity Read

The Molecular Genetics of Mycolic Acid BiosynthesisSemantic proximity Read

Genetic determination of the meso-diaminopimelate biosynthetic pathway of mycobacteria.Semantic proximity Read

Immunogenicity and protective efficacy of the Mycobacterium tuberculosis fadD26 mutant.Semantic proximity Read