Article
Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complex.
The Journal of biological chemistry - 8 Oct 2004
Pérez Esther, Constant Patricia, Laval Françoise, Lemassu Anne, Lanéelle Marie-Antoinette, Daffé Mamadou, Guilhot Christophe
Abstract excerpt
A few mycobacterial species, most of which are pathogenic for humans, produce dimycocerosates of phthiocerol (DIM) and of glycosylated phenolphthiocerol, also called phenolglycolipid (PGL), two groups of molecules shown to be important virulence factors. The biosynthesis of these molecules is a very complex pathway that involves more than 15 enzymatic steps and has just begun to be elucidated. Most of the genes...
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