Multiple deletions in the polyketide synthase gene repertoire of<i>Mycobacterium tuberculosis</i>reveal functional overlap of cell envelope lipids in host-pathogen interactions

Abstract excerpt

Several specific lipids of the cell envelope are implicated in the pathogenesis of M. tuberculosis (Mtb), including phthiocerol dimycocerosates (DIM) that have clearly been identified as virulence factors. Others, such as trehalose-derived lipids, sulfolipids (SL), diacyltrehaloses (DAT) and polyacyltrehaloses (PAT), are believed to be essential for Mtb virulence, but the details of their role remain unclear. We...

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• Mycobacterium research and diagnosis
• Pneumocystis jirovecii pneumonia detection and treatment
• Tuberculosis Research and Epidemiology