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Pleiotropic roles of Clostridium difficile sin locus

12 Mar 2018

Abstract excerpt

Clostridium difficile is the primary cause of nosocomial diarrhea and pseudomembranous colitis. It produces dormant spores, which serve as an infectious vehicle responsible for transmission of the disease and persistence of the organism in the environment. In Bacillus subtilis, the sin locus coding SinR (113 aa) and SinI (57 aa) is responsible for sporulation inhibition. In B. subtilis, SinR mainly acts as a...

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PMID: 29529083
DOI: 10.1371/journal.ppat.1006940

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