Article

On the prediction of DNA-binding preferences of C2H2-ZF domains using structural models: application on human CTCF

2019-11-29

Abstract excerpt

<h4>ABSTRACT</h4> Cis2-His2 zinc finger (C2H2-ZF) proteins are the largest family of transcription factors in human and higher metazoans. However, the DNA-binding preferences of many members of this family remain unknown. We have developed a computational method to predict these DNA-binding preferences. We combine information from crystal structures composed by C2H2-ZF domains and from bacterial one-hybrid experi...

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Literature Corpus work: 16792a38-573b-5b1c-b38f-0ce1c42b3aa5
DOI: 10.1101/859934

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