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Article

Exploiting the recognition code for elucidating the mechanism of zinc finger protein-DNA interactions.

BMC genomics - 22 Dec 2016

Dutta Shayoni, Madan Spandan, Sundar Durai

Abstract excerpt

BACKGROUND: Engineering zinc finger protein motifs for specific binding to double-stranded DNA is critical for targeted genome editing. Most existing tools for predicting DNA-binding specificity in zinc fingers are trained on data obtained from naturally occurring proteins, thereby skewing the predictions. Moreover, these mostly neglect the cooperativity exhibited by zinc fingers. METHODS: Here, we present an...

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Identifiers

PMID: 28155654
DOI: 10.1186/s12864-016-3324-8
PMCID: PMC5260074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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