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Article

Selective dimerization of a C2H2 zinc finger subfamily.

Molecular cell - 1 Feb 2003

McCarty Aaron S, Kleiger Gary, Eisenberg David, Smale Stephen T

Abstract excerpt

The C2H2 zinc finger is the most prevalent protein motif in the mammalian proteome. Two C2H2 fingers in Ikaros are dedicated to homotypic interactions between family members. We show here that these fingers comprise a bona fide dimerization domain. Dimerization is highly selective, however, as homologous domains from the TRPS-1 and Drosophila Hunchback proteins support homodimerization, but not heterodimerization...

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Identifiers

PMID: 12620233
DOI: 10.1016/s1097-2765(03)00043-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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