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Baricitinib Attenuates the Proinflammatory Phase of COVID-19 Driven by Lung-Infiltrating Monocytes

2021-11-08

Abstract excerpt

COVID-19 patients are generally asymptomatic during initial SARS-CoV-2 replication, but may suffer severe immunopathology after the virus has receded and blood monocytes have infiltrated the airways. In the bronchoalveolar lavage fluid from patients with severe COVID-19, lung-infiltrating monocytes expressed high mRNA levels encoding inflammatory mediators, including <i>CXCL8</i> and<i> IL-1ß</i>, and contained <i...

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Literature Corpus work
16734dc4-0f49-572a-b4c6-a1580d64c7bf
DOI
10.2139/ssrn.3959287
Open publication

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Baricitinib Attenuates the Proinflammatory Phase of COVID-19 Driven by Lung-Infiltrating MonocytesDOI 10.2139/ssrn.3959287
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