Article

Reduced Levels of Lagging Strand Polymerases Shape Stem Cell Chromatin

2024-04-29

Abstract excerpt

Stem cells display asymmetric histone inheritance while non-stem progenitor cells exhibit symmetric patterns in the Drosophila male germline lineage. Here, we report that components involved in lagging strand synthesis, such as DNA polymerase α and δ (Polα and Polδ), have significantly reduced levels in stem cells compared to progenitor cells. Compromising Polα genetically induces the replication-coupled histone...

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Literature Corpus work: 164fe61a-3c6b-5588-837e-1ca9e709bc27
DOI: 10.1101/2024.04.26.591383

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