Article

The role of MEGF10 in myoblast fusion and hypertrophic response to overload of skeletal muscle

2024-10-20

Abstract excerpt

Biallelic mutations in multiple EGF domain protein 10 ( MEGF10 ) gene cause EMARDD (early myopathy, areflexia, respiratory distress and dysphagia) in humans, a severe recessive myopathy, associated with reduced numbers of PAX7 positive satellite cells. To better understand the role of MEGF10 in satellite cells, we overexpressed human MEGF10 in mouse H-2k b -tsA58 myoblasts and found that it inhibited fusion. Add...

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Identifiers and source

Literature Corpus work: 1631783c-7a33-57af-a37d-4a8eb712277d
DOI: 10.1101/2024.10.19.619219

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