Article

Lamin-related congenital muscular dystrophy alters mechanical signaling and skeletal muscle growth

2020-08-06

Abstract excerpt

<h4>Background</h4> Laminopathies are a clinically heterogeneous group of disorders caused by mutations in the LMNA gene, which encodes the nuclear envelope proteins lamins A and C. The most frequent diseases associated with LMNA mutations are characterized by skeletal and cardiac involvement, and include autosomal dominant Emery-Dreifuss muscular dystrophy (EDMD), limb-girdle muscular dystrophy type 1B, and L...

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Literature Corpus work: 798aef9f-d25f-54ca-bf59-db1f7e5f7457
DOI: 10.1101/2020.08.06.239210

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