Article

MEGF10 Accelerates a Developing Niche to Improve Engrafted Progenitor Cell Retention in Dystrophic and Regenerating Skeletal Muscle

2026-04-17

Abstract excerpt

<title>Abstract</title> <p>Skeletal muscle cell therapies are limited by poor long-term engraftment, particularly in diseased muscle, where retention of a PAX7+ stem cell pool depends on formation of a supportive niche. Here, we used spatial transcriptomics to map niche development across engraftment time, healthy versus dystrophic microenvironments, and secondary injury. Engrafted myogenic cells underwent rapid...

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Literature Corpus work: da9b2861-e6f6-5e25-8eb7-a20ad78f6b5d
DOI: 10.21203/rs.3.rs-9408825/v1

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