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Article

Megf10 deficiency impairs skeletal muscle stem cell migration and muscle regeneration

7 Nov 2020

Abstract excerpt

Biallelic loss‐of‐function MEGF10 mutations lead to MEGF10 myopathy, also known as early onset myopathy with areflexia, respiratory distress, and dysphagia (EMARDD). MEGF10 is expressed in muscle satellite cells, but the contribution of satellite cell dysfunction to MEGF10 myopathy is unclear. Myofibers and satellite cells were isolated and examined from Megf10 −/− and wild‐type mice. A separate set of mice...

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PMID: 33159715
DOI: 10.1002/2211-5463.13031

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