Back to search

Article

Pancreatic tumor organoids for modeling in vivo drug response and discovering clinically-actionable biomarkers

2019-01-07

Abstract excerpt

Patient-derived models are transforming translational cancer research. It is not clear if the emergence of patient-derived organoid (PDO) models can extend the utility of the widely used patient-derived xenograft (PDX). In addition, the utility of PDO models for serum biomarker discovery is not known. Here, we demonstrate that PDO models recapitulate the genomics, cell biology, glycomics and drug responses observe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
162efb81-1394-525d-a0bb-ff808fb99045
DOI
10.1101/513267
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Pancreatic tumor organoids for modeling in vivo drug response and discovering clinically-actionable biomarkersDOI 10.1101/513267
Pancreatic adenocarcinoma human organoids share structural and genetic features with primary tumorsSemantic proximity
Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma TumorsSemantic proximity
Combining molecular characteristics and therapeutic analysis of PDOs predict clinical responses and guide PDAC personalized treatmentSemantic proximity
Pancreatic Cancer Patient-Derived Organoid Platforms: A Clinical Tool to Study Cell- and Non-Cell-Autonomous Mechanisms of Treatment ResponseSemantic proximity
Modelling of pancreatic cancer biology: transcriptomic signature for 3D PDX-derived organoids and primary cell line organoid developmentSemantic proximity
Pancreatic cancer patient-derived organoids capture therapy response and tumor evolutionSemantic proximity
Rapid and Multifaceted Characterization of the Effects of the Secreted EVome in Pancreatic Cancer: A Global Omics Approach for Screening Putative BiomarkersSemantic proximity
The Diverse Applications of Pancreatic Ductal Adenocarcinoma OrganoidsSemantic proximity
Patient-derived organoids to study glycosylation dynamics during gastric diseaseSemantic proximity
The application of organoids in treatment decision-making for digestive system cancers: progress and challengesSemantic proximity
Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchySemantic proximity
The Origin of Patient-Derived Cancer Organoids from Pathologically Undiagnosed Specimen in Patients with Pancreatobiliary CancersSemantic proximity
Select a neighboring publication to make it the new centre.