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Article

Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4.

Scientific reports - 25 May 2017

Liu Yi-Liang, Lee Chien-Yun, Huang Yu-Ni, Chen Hui-Yi, Liu Guang-Yaw, Hung Hui-Chih

Abstract excerpt

Our recent studies of peptidylarginine deiminase 4 (PAD4) demonstrate that its non-catalytic Ca2+-binding sites play a crucial role in the assembly of the correct geometry of the enzyme. Here, we examined the folding mechanism of PAD4 and the role of Ca2+ ions in the folding pathway. Multiple mutations were introduced into the calcium-binding sites, and these mutants were termed the Ca1_site, Ca2_site, Ca3_site,...

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Source

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Identifiers

PMID: 28546558
DOI: 10.1038/s41598-017-02677-1
PMCID: PMC5445078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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