Article

Harnessing natural diversity to identify key amino acid residues in prolidase

2018-09-21

Abstract excerpt

Prolidase (PEPD) catalyses the cleavage of dipeptides with high affinity for proline at the C-terminal end. This function is required in almost all living organisms. In order to detect strongly conserved residues in PEPD, we analysed PEPD orthologous sequences identified in data sets of animals, plants, fungi, archaea, and bacteria. Due to conservation over very long evolutionary time, conserved residues are likel...

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Literature Corpus work: ecdace9a-efb2-5edf-8122-147a29e3fae6
DOI: 10.1101/423475

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