Article

Integrative Behavioral, Histological and Proteomics Profiling Identifies Cerebellar Drivers of Motor Dysfunction in a Rat Model of Hepatic Encephalopathy

2025-06-10

Abstract excerpt

<title>Abstract</title> <p>Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome resulting from liver dysfunction or portosystemic shunting, characterized by cognitive and motor impairments. Although often considered reversible after liver transplantation, emerging evidence suggests HE may cause lasting neurological damage, underscoring the need to explore its molecular basis. The cerebellum, critica...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 162277e6-ddb7-5aca-ba29-251b0fa19f68
DOI: 10.21203/rs.3.rs-6690143/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative Behavioral, Histological and Proteomics Profiling Identifies Cerebellar Drivers of Motor Dysfunction in a Rat Model of Hepatic EncephalopathyDOI 10.21203/rs.3.rs-6690143/v1Read

Investigating Hippocampal Proteome Dynamics in Aging Rats with Minimal Hepatic Encephalopathy via High-Resolution Mass SpectrometrySemantic proximity Read

Dodecyl Creatine Ester Improves Cognitive Function and Identifies Drivers of Creatine DeficiencySemantic proximity Read

Lipid Dyshomeostasis and Inherited Cerebellar AtaxiaSemantic proximity Read

Systematic Phenotyping and Molecular Analysis of the Woozy Mouse: A Preclinical Model of Cerebellar Ataxia.Semantic proximity Read

Neurological Phenotypes in Mouse Models of Mitochondrial Disease and Relevance to Human Neuropathology.Semantic proximity Read

Quantitative Changes in the Mitochondrial Proteome of Cerebellar Synaptosomes From Preclinical Cystatin B-Deficient MiceSemantic proximity Read

Long-Term Benefits of TUDCA Supplement in ARSACS Zebrafish ModelSemantic proximity Read

Association of cerebellar inflammation and neurodegeneration in a novel spinocerebellar ataxia type 13 mouse modelSemantic proximity Read

Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsySemantic proximity Read

Purkinje Cell-specific Deficiency in SEL1L-HRD1 Endoplasmic Reticulum-Associated Degradation Causes Progressive Cerebellar Ataxia in MiceSemantic proximity Read

Improvement in Outcomes and Prevention of Multiple Organ Dysfunction Syndrome After Cardiac Arrest and Successful Cardiopulmonary Resuscitation by Systemic Administration of Bumetanide in Male MiceSemantic proximity Read

Proteomic Profiling of the Hippocampus of Rats Subjected to the Pilocarpine Model of EpilepsySemantic proximity Read