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Article

Structural basis of the zinc-induced cytoplasmic aggregation of the RNA-binding protein SFPQ

28 Jan 2020

Abstract excerpt

SFPQ is a ubiquitous nuclear RNA-binding protein implicated in many aspects of RNA biogenesis. Importantly, nuclear depletion and cytoplasmic accumulation of SFPQ has been linked to neuropathological conditions such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Here, we describe a molecular mechanism by which SFPQ is mislocalized to the cytoplasm. We report an unexpected discovery of the...

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PMID: 32034402
DOI: 10.1093/nar/gkaa076

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