Article

Cell composition, transcriptomic, and functional pathway changes in the hippocampus in Alzheimer’s disease and overlap with lead (Pb) exposure signatures

2026-07-22

Abstract excerpt

<h4>Background</h4> Lead (Pb) is associated with Alzheimer’s disease (AD); however, the relationships between Pb and AD hippocampal transcription remains unclear. We evaluated overlap between Pb-response signatures and cell-type-independent AD transcriptomic signatures. <h4>Method</h4> Three toxicology studies (two neuronal cell lines, one mouse hippocampus) provided Pb-response genes. Five human postmortem hipp...

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Literature Corpus work: 15ead24c-5c6f-57da-a193-4ea7da28e14c
DOI: 10.64898/2026.07.21.26358590

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Cell composition, transcriptomic, and functional pathway changes in the hippocampus in Alzheimer’s disease and overlap with lead (Pb) exposure signaturesDOI 10.64898/2026.07.21.26358590Read

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