Article

Identification of chemicals targeting dementia genes and pathways in the Comparative Toxicogenomics Database

2025-12-22

Abstract excerpt

<h4>Introduction</h4> Dementia is a public health challenge and exposures likely contribute to risk, though many have not been evaluated. We screened chemicals for enrichment with dementia genes and related pathways. <h4>Methods</h4> We obtained gene lists from the Comparative Toxicogenomics Database for 1,008 chemicals and nine dementia-related pathways (e.g., Alzheimer’s disease, tauopathies). We tested pairwi...

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Literature Corpus work: 8b998506-b6ab-593d-a203-1d9f9c0dd8ac
DOI: 10.64898/2025.12.19.695572

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