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The cell biology of Parkinson’s disease

22 Mar 2021

Abstract excerpt

Parkinson's disease (PD) is a progressive neurodegenerative disorder resulting from the death of dopamine neurons in the substantia nigra pars compacta. Our understanding of PD biology has been enriched by the identification of genes involved in its rare, inheritable forms, termed PARK genes. These genes encode proteins including α-syn, LRRK2, VPS35, parkin, PINK1, and DJ1, which can cause monogenetic PD when...

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PMID: 33749710
DOI: 10.1083/jcb.202012095

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