Article

Glioblastoma recurrence and the role of MGMT promoter methylation

2018-05-09

Abstract excerpt

Tumor recurrence in glioblastoma multiforme (GBM) is often attributed to acquired resistance to the standard chemotherapeutic agent temozolomide (TMZ). Promoter methylation of the DNA repair gene MGMT has been associated with sensitivity to TMZ, while increased expression of MGMT has been associated with TMZ resistance. Clinical studies have observed a downward shift in MGMT methylation percentage from primary to...

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Literature Corpus work: 15891018-c37f-57f8-8f14-c6ececaec8ec
DOI: 10.1101/317636

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