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Glioblastoma Recurrence and the Role of O<sup>6</sup>-Methylguanine–DNA Methyltransferase Promoter Methylation

13 Feb 2019

Abstract excerpt

-methylguanine-DNA methyltransferase) has been associated with sensitivity to TMZ, whereas increased expression of MGMT has been associated with TMZ resistance. Clinical studies have observed a downward shift in MGMT methylation percentage from primary to recurrent stage tumors; however, the evolutionary processes that drive this shift and more generally the emergence and growth of TMZ-resistant tumor...

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PMID: 30758983
DOI: 10.1200/cci.18.00062

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