Article

CAR-Cytotox: A Standardized Framework to Quantify Cytotoxic Potency in CAR T Cell Products

2026-05-14

Abstract excerpt

<title>Abstract</title> <p> Chimeric antigen receptor (CAR) T cell therapy is a revolutionizing treatment, but its functional potency varies widely across donors, manufacturing runs, and patients. However, routine product release testing rarely measures cytotoxic competence. We introduce a standardized framework that integrates complementary readouts following 48 hour CD19-bead stimulation: degranulation by flow...

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Literature Corpus work: 1577c9fd-57a6-55c8-82ab-086954600144
DOI: 10.21203/rs.3.rs-9287376/v1

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