Article

Engineering a Vaccine Platform using Rotavirus A to Express SARS-CoV-2 Spike Epitopes

2022-03-27

Abstract excerpt

<h4>ABSTRACT</h4> Human rotavirus (RV) vaccines used worldwide have been developed using live attenuated platforms. The recent development of a reverse genetics system for RVs has delivered the possibility of engineering chimeric viruses expressing heterologous peptides from other virus species to generate polyvalent vaccines. We tested the feasibility of this using two approaches. Firstly, we inserted short SARS...

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Literature Corpus work: 1571f67a-a58b-553a-85e1-12687ce50a82
DOI: 10.1101/2022.03.23.485570

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