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Recombinant rotavirus expressing the glycosylated S1 protein of SARS-CoV-2

13 Oct 2023

Abstract excerpt

Reverse genetic systems have been used to introduce heterologous sequences into the rotavirus segmented double-stranded (ds)RNA genome, enabling the generation of recombinant viruses that express foreign proteins and possibly serve as vaccine vectors. Notably, insertion of SARS-CoV-2 sequences into the segment seven (NSP3) RNA of simian SA11 rotavirus was previously shown to result in the production of...

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PMID: 37830788
DOI: 10.1099/jgv.0.001899

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