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Rearranged Genomic RNA Segments Offer a New Approach to the Reverse Genetics of Rotaviruses

29 Apr 2010

Abstract excerpt

Group A rotaviruses (RV), members of the Reoviridae family, are a major cause of infantile acute gastroenteritis. The RV genome consists of 11 double-stranded RNA segments. In some cases, an RNA segment is replaced by a rearranged RNA segment, which is derived from its standard counterpart by partial sequence duplication. We report here a reverse genetics system for RV based on the preferential packaging of...

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Identifiers

PMID: 20427539
DOI: 10.1128/jvi.00547-10

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