Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19: Protection of mice after a single immunization

21 Apr 2021

Abstract excerpt

Vaccines of outstanding efficiency, safety, and public acceptance are needed to halt the current SARS-CoV-2 pandemic. Concerns include potential side effects caused by the antigen itself and safety of viral DNA and RNA delivery vectors. The large SARS-CoV-2 spike (S) protein is the main target of current COVID-19 vaccine candidates but can induce non-neutralizing antibodies, which might cause vaccination-induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Virus Infections Studies
Share to SARS-CoV-2 and COVID-19 Research
Share to Viral Infections and Outbreaks Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33882114
DOI: 10.1371/journal.ppat.1009064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19: Protection of mice after a single immunizationPMID 33882114Read ↗

DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in miceSemantic proximity Read ↗

Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization with a versatile adenovirus-inspired multimerization platformSemantic proximity Read ↗

Immunogenicity of a new gorilla adenovirus vaccine candidate for COVID-19Semantic proximity Read ↗

SARS-CoV-2–Specific Vaccine Candidates; the Contribution of Structural VaccinologySemantic proximity Read ↗

A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccinesSemantic proximity Read ↗

A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaquesSemantic proximity Read ↗

Immunization with recombinant accessory protein-deficient SARS-CoV-2 protects against lethal challenge and viral transmissionSemantic proximity Read ↗

A Highly Immunogenic and Protective Middle East Respiratory Syndrome Coronavirus Vaccine Based on a Recombinant Measles Virus Vaccine PlatformSemantic proximity Read ↗

A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type and Delta variantsSemantic proximity Read ↗

Rational design of an influenza-COVID-19 chimeric protective vaccine with HA-stalk and S-RBDSemantic proximity Read ↗

A Potential Novel COVID-19 Vaccine With RBD-HR1/HR2 Hexamer StructureSemantic proximity Read ↗

Development and immunogenicity evaluation of a quadruple-gene-deleted pseudorabies virus strainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.