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Article

Rotavirus as an Expression Platform of Domains of the SARS-CoV-2 Spike Protein

3 May 2021

Abstract excerpt

Among vaccines administered to children are those targeting rotavirus, a segmented double-stranded RNA virus that represents a major cause of severe gastroenteritis. To explore the feasibility of establishing a combined rotavirus-SARS-CoV-2 vaccine, we generated recombinant (r)SA11 rotaviruses with modified segment 7 RNAs that contained coding cassettes for NSP3, a translational 2A stop-restart signal, and a...

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Identifiers

PMID: 34063562
DOI: 10.3390/vaccines9050449

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