Mechanisms sensitive to different drugs mediate a proadhesive and pro-thrombotic platelet phenotype in antiphospholipid syndrome.

doi:10.3324/haematol.2024.287133

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Article

Mechanisms sensitive to different drugs mediate a proadhesive and pro-thrombotic platelet phenotype in antiphospholipid syndrome.

Haematologica - 1 Jan 2026

Camera Marina, Brambilla Marta, Lonati Paola Adele, Becchetti Alessia, Grossi Claudia, Nallio Kevin, Da Via Arianna, Trespidi Laura, Borghi Maria Orietta, Tedesco Francesco, Meroni Pier Luigi

Abstract excerpt

Anti-phospholipid antibodies (aPL) mediate platelet- and leukocyte-interaction with damaged endothelium, contributing to anti-phospholipid syndrome (APS) vasculopathy. This study aimed to understand the mechanisms sustaining the pro-adhesive/- thrombotic platelet phenotype and the in vitro effects of different drugs. We included 34 primary APS (PAPS) patients and 12 healthy subjects (HS). All patients had...

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PMID: 40605716
DOI: 10.3324/haematol.2024.287133
PMCID: PMC12775784

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