Article

A single droplet digital PCR for <i>ESR1</i> activating mutations detection in plasma

2019-01-08

Abstract excerpt

<h4>Background</h4> Activating mutations in the estrogen receptor 1 ( ESR1 ) gene are recurrent mechanisms of acquired resistance to aromatase inhibitors (AI), and may be the target of other selective estrogen receptor down-regulators. To assess the clinical utility of monitoring ESR1 resistant mutations, a droplet digital PCR (ddPCR)-based assay compatible with body fluids is ideal due to its cost-effectivenes...

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Literature Corpus work: 15555d52-695b-5d69-9a6e-7a455b3fde24
DOI: 10.1101/507608

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