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Real-Time Detection of ESR1 Mutation in Blood by Droplet Digital PCR in the PADA-1 Trial: Feasibility and Cross-Validation with NGS.

Analytical chemistry - 26 Apr 2022

Callens Celine, Bidard Francois-Clement, Curto-Taribo Anaïs, Trabelsi-Grati Olfa, Melaabi Samia, Delaloge Suzette, Hardy-Bessard Anne-Claire, Bachelot Thomas, Clatot Florian, De La Motte Rouge Thibault, Canon Jean-Luc, Arnould Laurent, Andre Fabrice, Marques Sandrine, Stern Marc-Henri, Pierga Jean-Yves, Vincent-Salomon Anne, Benoist Camille, Jeannot Emmanuelle, Berger Frederique, Bieche Ivan, Pradines Anne

Abstract excerpt

The clinical actionability of circulating tumor DNA requires sensitive detection methods with a short turnaround time. In the PADA-1 phase 3 trial (NCT03079011), metastatic breast cancer patients treated with an aromatase inhibitor and palbociclib were screened every 2 months for activating ESR1 mutations in blood (bESR1mut). We report the feasibility of the droplet digital polymerase chain reaction (ddPCR) and...

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PMID: 35416669
DOI: 10.1021/acs.analchem.2c00446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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