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Article

Droplet digital polymerase chain reaction assay for screening of ESR1 mutations in 325 breast cancer specimens.

Translational research : the journal of laboratory and clinical medicine - 1 Dec 2015

Takeshita Takashi, Yamamoto Yutaka, Yamamoto-Ibusuki Mutsuko, Inao Toko, Sueta Aiko, Fujiwara Saori, Omoto Yoko, Iwase Hirotaka

Abstract excerpt

Droplet digital polymerase chain reaction (ddPCR), which could perform thousands of PCRs on a nanoliter scale simultaneously, would be an attractive method to massive parallel sequencing for identifying and studying the significance of low-frequency rare mutations. Recent evidence has shown that the key potential mechanisms of the failure of aromatase inhibitors-based therapy involve identifying activating...

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Source

Identifiers

PMID: 26434753
DOI: 10.1016/j.trsl.2015.09.003

Genes

ESR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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