Sensitive Detection of Mono- and Polyclonal ESR1 Mutations in Primary Tumors, Metastatic Lesions, and Cell-Free DNA of Breast Cancer Patients.

doi:10.1158/1078-0432.CCR-15-1534

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Article

Sensitive Detection of Mono- and Polyclonal ESR1 Mutations in Primary Tumors, Metastatic Lesions, and Cell-Free DNA of Breast Cancer Patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2016

Wang Peilu, Bahreini Amir, Gyanchandani Rekha, Lucas Peter C, Hartmaier Ryan J, Watters Rebecca J, Jonnalagadda Amruth R, Trejo Bittar Humberto E, Berg Aaron, Hamilton Ronald L, Kurland Brenda F, Weiss Kurt R, Mathew Aju, Leone Jose Pablo, Davidson Nancy E, Nikiforova Marina N, Brufsky Adam M, Ambros Tadeu F, Stern Andrew M, Puhalla Shannon L, Lee Adrian V, Oesterreich Steffi

Abstract excerpt

PURPOSE: Given the clinical relevance of ESR1 mutations as potential drivers of resistance to endocrine therapy, this study used sensitive detection methods to determine the frequency of ESR1 mutations in primary and metastatic breast cancer, and in cell-free DNA (cfDNA). EXPERIMENTAL DESIGN: Six ESR1 mutations (K303R, S463P, Y537C, Y537N, Y537S, D538G) were assessed by digital droplet PCR (ddPCR), with lower...

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PMID: 26500237
DOI: 10.1158/1078-0432.CCR-15-1534
PMCID: PMC4775406

Genes

ESR1

Variants

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