Article
ESR1 Mutations in Breast Cancer: Proof-of-Concept Challenges Clinical Action.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2016
Gu Guowei, Fuqua Suzanne A W
Abstract excerpt
Wang and colleagues demonstrate that digital droplet PCR (ddPCR) identified ESR1 mutations in 7% of primary breast cancers. ESR1 mutations were also readily detected in metastatic tissues and circulating tumor DNA in the blood. These results suggest that ddPCR may be amendable for monitoring tumor burden, and to predict relapse. See related article by Wang et al., p. 1130.
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