Article

HOPS is required for non-canonical mTORC1 signaling by recruiting Rags and FLCN to lysosomal membranes

2026-05-15

Abstract excerpt

The mechanistic target of Rapamycin complex 1 (mTORC1) regulates cell growth and metabolism in response to nutrient availability. mTORC1 recruitment to lysosomes by the Rag dimer complex (RagA/B and RagC/D) is a crucial step in mTORC1 signaling. Substrates of the MiT/TFE transcription factor family, like TFEB and TFE3, directly interact with the Rag complex when activated by folliculin (FLCN). This selective recru...

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Literature Corpus work: 154c725c-7d42-5d30-ae76-e40d2fd2c51b
DOI: 10.64898/2026.05.14.724810

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