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Article

The electrophysiologic effects of KCNQ1 extend beyond expression of IKs: evidence from genetic and pharmacologic block

5 Mar 2024

Abstract excerpt

AIMS: While variants in KCNQ1 are the commonest cause of the congenital long QT syndrome, we and others find only a small IKs in cardiomyocytes from human-induced pluripotent stem cells (iPSC-CMs) or human ventricular myocytes. METHODS AND RESULTS: We studied population control iPSC-CMs and iPSC-CMs from a patient with Jervell and Lange-Nielsen (JLN) syndrome due to compound heterozygous loss-of-function (LOF)...

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Share to Cardiac Arrhythmias and Treatments
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PMID: 38442735
DOI: 10.1093/cvr/cvae042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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