DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets.

doi:10.1158/1078-0432.CCR-15-3011

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DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2016

Hanaford Allison R, Archer Tenley C, Price Antoinette, Kahlert Ulf D, Maciaczyk Jarek, Nikkhah Guido, Kim Jong Wook, Ehrenberger Tobias, Clemons Paul A, Dančík Vlado, Seashore-Ludlow Brinton, Viswanathan Vasanthi, Stewart Michelle L, Rees Matthew G, Shamji Alykhan, Schreiber Stuart, Fraenkel Ernest, Pomeroy Scott L, Mesirov Jill P, Tamayo Pablo, Eberhart Charles G, Raabe Eric H

Abstract excerpt

PURPOSE: We used human stem and progenitor cells to develop a genetically accurate novel model of MYC-driven Group 3 medulloblastoma. We also developed a new informatics method, Disease-model Signature versus Compound-Variety Enriched Response ("DiSCoVER"), to identify novel therapeutics that target this specific disease subtype. EXPERIMENTAL DESIGN: Human neural stem and progenitor cells derived from the...

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PMID: 27012813
DOI: 10.1158/1078-0432.CCR-15-3011
PMCID: PMC5055054

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