Article

Effect of Aging on the Human Myometrium at Single-Cell Resolution

2023-07-03

Abstract excerpt

The myometrial dysfunction associated with aging can prompt complications during pregnancy and labor, causing a 7.8-fold increase in maternal mortality in women over 40. Using single-cell/single-nucleus RNA sequencing and spatial transcriptomics, we constructed a cellular atlas of the aging myometrium from 186,120 cells across twenty peri- and post-menopausal women. We identified 23 myometrial cell subpopulations,...

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Literature Corpus work: 226ac3b3-896a-5d15-af41-7453efdfa4a0
DOI: 10.1101/2023.07.03.547452

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