Article

<i>CDKN2C</i> homozygous loss identifies a distinct subtype of <i>TP53/RB1</i> -wildtype leiomyosarcoma with frequent <i>CIC</i> genomic alterations and 1p/19q-codeletion

2020-03-04

Abstract excerpt

<h4>Purpose</h4> Leiomyosarcomas (LMS) harbor frequent inactivation of TP53 and RB1 , and extensive DNA copy number alterations. Here, we describe a distinct recurrent genomic signature in TP53 / RB1 -wildtype uterine LMS. <h4>Methods</h4> Tissues from 276,645 unique advanced cancers, including 2,570 uterine and soft tissue LMS were sequenced by hybrid-capture-based next-generation DNA and RNA sequencing/co...

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Literature Corpus work: 14f05d92-78f9-5c14-ae5b-6d0226dc1ea3
DOI: 10.1101/2020.03.02.973305

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