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Multiple human transgenes prolong survival of triple-carbohydrate knockout porcine kidney xenografts in nonhuman primates

2025-03-18

Abstract excerpt

<title>Abstract</title> <p> Genetically modified pigs are being developed to address the critical shortage of human organs for transplantation. We have previously demonstrated significantly prolonged survival of porcine xenografts devoid of three major carbohydrate xenoantigens (3KO) by incorporating human transgenes (HTGs). However, the optimal HTG combination and the mechanisms underlying improved xenograft su...

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Literature Corpus work
2760fd88-0536-54ab-bc92-4a2e65d4dceb
DOI
10.21203/rs.3.rs-6017857/v1
Open publication

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Multiple human transgenes prolong survival of triple-carbohydrate knockout porcine kidney xenografts in nonhuman primatesDOI 10.21203/rs.3.rs-6017857/v1
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