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Immunological and physiological observations in baboons with life‐supporting genetically engineered pig kidney grafts

1 Mar 2017

Abstract excerpt

BACKGROUND: Genetically engineered pigs could provide a source of kidneys for clinical transplantation. The two longest kidney graft survivals reported to date have been 136 and 310 days, but graft survival >30 days has been unusual until recently. METHODS: Donor pigs (n=4) were on an α1,3-galactosyltransferase gene-knockout (GTKO)/human complement regulatory protein (CD46) background (GTKO/CD46). In addition,...

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PMID: 28303661
DOI: 10.1111/xen.12293

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